Turning Waste into Value: A Pathway to Upcycling

When it comes to natural resources and the climate crisis, cutting back on waste and boosting sustainability are more important than ever before. Food waste alone is responsible for half of agriculture-related greenhouse gas emissions and is a major cause of environmental damage. Fortunately, innovative solutions are coming to the rescue, and one of them is waste upcycling through bioconversion, which uses naturally occurring and/or engineered microbes to convert food waste into valuable products like bioplastics.

What is Upcycling?

It’s the process of transforming waste into new products of higher value, like when someone finds an old piece of furniture on the roadside, gives it a new coat of paint, and makes it better than new. A new program called wasteCANcreate is doing exactly this, with a high-tech spin!

Ontario Genomics, Agriculture & Agri-Food Canada and industry partners have come together to convert food waste (what you put into your green bin) into various products that would normally be made from oil. Microbial upcycling of food waste into bioplastics puts microorganisms like bacteria and yeasts to work to convert the food waste into bioplastics, textiles like nylon, and other useful materials.

The three main goals for this project:

  1. Reduce greenhouse gas emissions from sources like decomposing food waste
  2. Eliminate our need for fossil fuels to create necessary materials
  3. Create lasting economic opportunities for Canadian industries

Novel ideas like this are being brought to life to revolutionize manufacturing processes and are a key part of the circular economy, which aims to cut waste and pollution, repair damaged ecosystems, and have a positive impact on the world economy.

Initiative members at a workshop in the Spring of 2023.

Initiative members at a workshop in the Spring of 2023. This initiative brings together world-class academic leaders, innovative industry partners, and others to accelerate the development and testing of bioplastics for various applications.

Microbes to the Rescue!

Microbes can be used as tiny factories and are at work all around us – think about your gut flora and the microbes that help make beer, yogurt, and bread. Putting them to use helps reduce our need for traditional plastics, which are most often non-biodegradable and a significant threat to the environment. Bioplastics, on the other hand, are made from biological raw materials and decompose more easily.

Plastics are everywhere you look. Plastic bags, cutlery, containers, and toys are obvious examples, but plastics are also found in most clothing, vehicles, furniture, and even in cosmetics and sunscreens! Plastics are cheap to make and last a long time, making them hard to get rid of. In Canada alone, we produce 4.8 million tons of plastic each year and 29,000 tons end up in the environment, including our waterways.

The upcycling process involves using microorganisms to break down the waste material and convert it into organic acids. These organic acids are then used to produce biodegradable plastics and additives for other products. Biodegradable plastics can replace oil-based plastics, meaning they will be much more easily disposed of and won’t stay in the environment for centuries to come.

The upcycling process
Curbing Greenhouse Gas Emissions

When food waste is sent to landfills, it decomposes and released methane gas into the atmosphere. Methane is a greenhouse gas and a major contributor to global warming that is over 25 times more potent than carbon dioxide! So, when we upcycle food waste into bioplastics, we reduce the waste sent to landfills and minimize the production of methane gas.

Economic Benefits

Since there’s no shortage of global waste, using it as a key ingredient for bioplastics is a brilliant idea! The food waste we have now costs us money to handle and store it while it decomposes. This means that any value extracted from this resource will help improve the economy as a whole. The process also creates a circular economy where waste becomes a valuable resource.

Upcycling food waste into bioplastics is an innovative, yet common sense solution for the very real problem of waste management facing Canada and the world. The best part is, the wasteCANcreate program is already at work perfecting this process so it can be used across the country and around the world.

Stay in the loop on exciting developments in our circular future!

This is the first in a series of blog posts detailing wasteCANcreate, Canada’s biomanufacturing opportunities, and the shift towards a circular economy. Stay tuned for more!

Blog: Look How Far We’ve Come

Happy DNA Day – Look how far we’ve come!

It was 71 years ago when scientists published groundbreaking research on the structure of DNA. That teamwork grew to become the internationally funded Human Genome Project which culminated in the most complete mapping of the human genome in May 2021. Genomics is all about DNA, and it’s DNA that tells us about life in all forms. It’s the basis of biology which is now fuelling biotechnology innovation. These technologies now have the power to move us away from environmentally damaging manufacturing methods.

After all, climate, food and health are all connected. Climate change is disastrous for food production and supply chains, as well as the health and well-being of everyone on this planet. The good news is, incredible solutions and technologies to address all of these very serious problems currently exist, likely in your own backyard!

Ontario Genomics has been leading the charge in the province since 2000 by supporting cutting-edge science to find homegrown solutions to challenges the world faces like climate change, food insecurity and in healthcare. We’ve done this by raising more than $3.7 billion for genomics applied research in the province which has created more than 20,000 jobs. We have over 330 projects and more than 500 partnerships!

Whether you realize it or not, DNA is all around us. What began decades ago as research to better understand what humans are made of, has since bloomed to include new ways of producing food and improving agricultural techniques as well as clean technology which is providing a new path to make and power the things we need.

One example is the wasteCANcreate program, which is bringing together Canadian researchers and industry partners in Aylmer, Burlington, Orillia, Vancouver and Regina spanning the energy, agriculture and food, plastic films and performance textiles sectors to bring real-world solutions to Ontario, Canada, and the rest of the world.

By using precision fermentation, microbes are used to turn food waste like potato peels into usable products like biodegradable plastics and fibres to create yoga pants! This new method of upcycling also reduces greenhouse gas emissions, replaces the need for petroleum-based plastics and is an economic boost to the province through job creation.

According to Ontario Genomics’ 2021 Cellular Agriculture Report, food biomanufacturing alone could explode to become a $7.5 billion industry creating 86,000 jobs by 2030, with greater growth projected in the long term. That’s why we’re involved with several food and agriculture projects and companies around the province, including the biggest Canadian cellular agriculture project ever that is led by McMaster University where researchers are developing efficient and economical ways to produce cultivated meat on a large scale.

While more commonly heard of cellular/cultivated products like red meat, poultry, seafood, foie gras and pet food are being made, dairy, eggs, honey and even chocolate are created through the same process! Food ingredients like these proteins, enzymes, flavour molecules, vitamins, pigments and fats can also be incorporated with existing products to create hybrid foods. This cellular agriculture technology is also creating textiles such as leather, wool, silk and cotton.

Amazing innovations like this may have seemed like a sci-fi fantasy years ago, but DNA is currently inspiring these kinds of creations here in Ontario. Work like this being done in this province can help propel Canada into global powerhouse status in the biotech-based economy. One way we’re helping to make this happen is through our annual SynBio conference that brings together national and international leaders in the field of engineering biology to build inter-sector partnerships.

Ontario Genomics has a very exciting partnership with FedDev Ontario for our BioCreate accelerator program that provides financial support, business and technical guidance to start-ups in southern Ontario to move the province’s biotechnology scene forward and get game-changing solutions scaled up and put into real world use as quickly as possible.

We’re currently supporting 16 companies in the health, cleantech and food and agriculture sectors, with more on the way! There are a lot of very smart and capable people doing amazing things in the province and it’s also incredibly encouraging to see that half of these companies are either run by women CEOs or have women on their leadership team. That stat alone shows science has also evolved greatly over the years, especially when you consider Rosalind Franklin’s discovery of DNA’s structure in 1953 has been greatly overlooked in the history books.

With all this in mind, we wish you a happy DNA Day – it’s incredible how far we’ve come, and you should feel a part of where we’re going!

Blog: Cracking the Rare Disease Code

EpiSign’s groundbreaking work in Ontario for the world

For years, Ontarians have been hearing about our crumbling health care system but there are many silver linings to the cloudy situation our hospitals are dealing with.

One of them is the groundbreaking work Dr. Bekim Sadikovic at Lawson Health Research Institute and London Health Sciences Centre has been doing with biotech company, Illumina. In their quest to better detect rare diseases, Dr. Sadikovic has created the clinically validated EpiSign test, which uses machine-learning algorithms and compiles them into the EpiSign™ Knowledge Database.

EpiSign: Cracking the Rare Disease Code

Thanks to funding from Ontario Genomics, Genome Canada and their Genomic Applications Partnership Program (GAPP), the EpiSign™ project is helping doctors cut down on long and agonizing diagnosis wait times by efficiently bringing answers and treatment options to more of the 1 in 15 Canadian children born with a rare disease.

Not only does this mean peace of mind and quicker access to the right support for those children, it’s critical relief to our health care system by speeding up the diagnosis process and easing the pressure on hospitals since 1 in 4 pediatric hospital beds are occupied by a child with a rare disease.

Dr. Bekim Sadikovic at Lawson Health Research Institute and London Health Sciences Centre

This incredible work has been an evolution. After all, projects like these don’t happen overnight! It takes many years of collaboration and many rounds of funding. When Dr. Sadikovic’s team applied for their first round of GAPP funding in 2019, they were able to detect 19 different disorders across 30 genes. Five years later, the most recent version of EpiSign™ has 116 different indicators covering 126 disorders. This number will only continue to grow in the years to come and while this much needed innovation was created here in Ontario, it’ll be a benefit to the rest of the world.

BioCreate Cohorts 4 & 5 are now open

BioCreate Program

Ontario Genomics’ BioCreate program is now open to small- and medium-sized enterprises (SMEs) in southern Ontario looking to commercialize genomics and engineering biology enabled products and/or technologies in the health, food and agriculture, and cleantech sectors at a Technology Readiness Level (TRL) of 4+.

What does BioCreate do? We provide funding, access to mentorship and business support to help companies bring new products and technologies to market.

Program Highlights:
  • Direct, non-repayable funding of $150,000.
  • Access to 18 months of intensive business mentorship and critical infrastructure provided by Ontario Genomics’ strategic sectoral and regional partnerships.
  • An investor showcase for each cohort, giving companies the opportunity to pitch to investors and potential partners.
Biocreate header with three phases
Application Steps and Dates

Interested? Review the Program Guide for more information on BioCreate, including eligibility requirements and evaluation criteria, then fill out the BioCreate intake form and a representative from our team will reach out to discuss your project idea. Eligible applicants will be invited to submit an application.

If you have questions, please contact BioCreate@ontariogenomics.ca.

The deadline to submit an intake form for Cohort 4 & 5 is June 23, 2024. Additional details and the application process can be found on the BioCreate page.

Complete the intake form now to find out more about your company’s eligibility!


The BioCreate program is supported by the Government of Canada through the Federal Economic Development Agency for Southern Ontario (FedDev Ontario) and Ontario Genomics. The current budget is greater than $7 million over five years.

Canada SynBio 2024 – Unlocking the Future

Registration for Canada SynBio 2024 is officially open!

Canada’s premier engineering biology event happens October 7-9 in Toronto.

The 6th annual Canada SynBio conference gives national and international engineering (synthetic) biology leaders the chance to connect, create inter-sector partnerships and help Canada become the major player in the global bioeconomy we know it can be. This year’s theme is Unlocking the Future.

Along with the networking opportunities are hearing from experts in the field. We are excited to announce our first keynote speaker: Dr. Cindy Gerhardt, Founder and CEO, Planet-B.io. Dr. Gerhardt is a visionary and innovator who spearheads a national open innovation ecosystem for biotech and food tech in the Netherlands. Her guiding principles are simple: respect people, animals and our planet.

Dr. Cindy Gerhardt, Founder and CEO, Planet-B.io

Our dynamic conference program features a wide range of presentation topics including:

  • Cellular agriculture
  • Bioconversion
  • AI and health
  • Strategy and policy frameworks
  • Training
  • Entrepreneurship
  • Mining solutions

You’ll also get the chance to participate in immersive networking events and be inspired by cutting-edge academics, start-ups, and established industry leaders.

Register today to take advantage of early-bird registration rates. Prices go up on June 1.

If you’re interested in becoming a partner at Canada SynBio, please email Luana Fiorotto at LLanglois@ontariogenomics.ca.

Ontario Genomics Welcomes New Interim Leadership

As an update to the recent resignation of our President and CEO, Bettina Hamelin, Ontario Genomics is thrilled to announce our interim leadership team, effective Monday April 1.

We are pleased to share that Stephen Cummings, a familiar face from our board of directors, will be stepping into the role of Interim CEO on a part-time basis over the next six months. Under the direction of the Board of Directors and in close collaboration with our management team, Stephen will oversee the strategic direction of our organization and support the Board in the recruitment process for the new President and CEO. Stephen brings over 30 years of extensive experience in financial and executive leadership roles. His nine-year tenure on our board, coupled with his expertise in strategic business advisory as CEO of Rizolve Partners and private equity / venture capital, uniquely positions him to guide us through this transition period with a steady hand.

Additionally, Jordan Thomson, currently serving as our Vice-President of Strategic Partnerships and Programs, will assume the responsibilities of Interim COO for the next six months. In this role, Jordan will provide continuity of Ontario Genomics operations in close collaboration with our management team, overseeing the daily operations and managing the team. Jordan’s impressive 16-year career spanning industries such as chemical process development, strategy, and business support, makes him an ideal candidate for this role. His track record of driving growth and fostering partnerships within Ontario Genomics underscores his commitment to our organization’s mission.

Together, Stephen and Jordan will collaborate closely with the Board of Directors and leadership team to ensure continuity, success, and a seamless transition for Ontario Genomics. Their collective expertise and dedication will propel us forward as we continue to innovate and make meaningful contributions to the genomics and engineering biology landscape in Ontario and beyond.

Please join us in welcoming Stephen and Jordan to their new roles! We thank you for your continued support and partnership as we embark on this journey together.

Ontario Genomics Welcomes New Interim Leadership

 

Ontario Biotech Start-ups Get Government Funding and Business Support

Four local companies are putting Ontario on the global biomanufacturing map

Four new start-ups have been welcomed into BioCreate, Ontario Genomics’ $11.6-million accelerator program providing financial and business support to biotechnology companies that are creating game-changing solutions in the health, food and agriculture, and cleantech industries.

BioCreate is funded by Ontario Genomics and a Government of Canada investment of over $5.6 million, through the Federal Economic Development Agency for Southern Ontario (FedDev Ontario). The program connects highly vetted companies with $150,000 in funding, 18 months of business mentorship and access to critical infrastructure to scale up their products. They’ll also get the opportunity to pitch to investors for further funding.

Here are this round’s recipients:

  • AuX Labs (Toronto) is using precision fermentation to create a vegan version of casein (a natural protein in cow’s milk) to make vegan cheese that melts, stretches, and tastes just like the animal product-based version.
  • Genuine Taste (Toronto) is giving both cultivated meat and plant-based meat better flavour, aroma and texture with their ethical and sustainable cultivated beef fat.
  • mDETECT Inc. (Kingston) has developed highly sensitive blood tests that detect six of the most common cancers and also let doctors know how the cancer is responding to treatment.
  • Scispot.io Inc (Kitchener) is simplifying access to data to make it quicker and easier for drug researchers to organize and accurately interpret findings, getting medications to market faster.

These four companies beat out 33 other applicants to join the 12 health, food and agriculture, and cleantech start-ups that were accepted into the BioCreate program last year.

“Congratulations to the four companies that have joined the BioCreate program as they work to improve the lives of Canadians while creating economic opportunities,” says the Honourable Filomena Tassi, Minister responsible for FedDev Ontario. “It’s our government’s priority to support emerging companies in the health, food, agriculture and cleantech industries so they have access to the tools and resources they need grow and thrive.”

Ontario Genomics President and CEO, Dr. Bettina Hamelin, says, “This game-changing innovation is happening right here in Ontario, creating jobs and advances in the food and agriculture, clean tech and health sectors. We’re also excited these technologies are good for Canadians, as well as people and businesses around the world.”


About Ontario Genomics
Ontario Genomics is a non-profit organization funded by the Government of Ontario and other partners. Since 2000, we’ve been involved with cutting-edge science to find homegrown solutions to challenges the world faces like climate change, food insecurity and in healthcare. Find out more at OntarioGenomics.ca.

About FedDev Ontario
For 14 years, the Government of Canada, through FedDev Ontario, has worked to advance and diversify the southern Ontario economy through funding opportunities and business services that support innovation, growth and job creation in Canada’s most populous region. The Agency has delivered impressive results, which can be seen in southern Ontario businesses that are creating innovative technologies, improving productivity, growing revenues, creating jobs, and in the economic advancement of communities across the region. Learn more about the impacts the Agency is having in southern Ontario by exploring our pivotal projects, our Southern Ontario Spotlight, and FedDev Ontario’s TwitterFacebookInstagram and LinkedIn.

-30-

Media Contacts
Maggie Blood
Innovation Communications and Public Affairs Manager
mblood@ontariogenomics.ca

Edward Hutchinson
Press Secretary
Office of the Minister responsible for the Federal Economic Development Agency for Southern Ontario
edward.hutchinson@feddevontario.gc.ca

Ontario Genomics Leadership Update

With mixed emotions, we share news of an important change at Ontario Genomics. Effective March 29, 2024, Dr. Bettina Hamelin, our esteemed President and CEO since August 2017, will be leaving the organization to pursue an exciting new opportunity at Innovative Medicines Canada (IMC). IMC is the national association representing the voice of 48 innovative pharmaceutical companies in Canada. Here, Bettina will continue to take important strides to advance our innovation ecosystem and advocate for policies that enable the discovery, development, and delivery of innovative medicines and vaccines to improve the lives of all Canadians.

Under Bettina’s leadership, Ontario Genomics has flourished, achieving milestones that have marked historic moments in our 24-year history. Her visionary leadership has not only put Ontario Genomics on the map locally, nationally, and internationally but also delivered extraordinary outcomes that have advanced our broader ecosystem.

We extend our deepest appreciation to Bettina, and highlight some of her profound successes over the last 6 years:

  • Leading unprecedented success for our research community, attracting more federal Genome Canada funding and Ontario government project co-funding than ever before;
  • Advancing cutting-edge commercialization of Ontario’s world-leading research with the creation of the Landing Pad and programs;
  • Creating the first-in-class Canadian waste upcycling consortium, , to provide solutions for our global waste crisis;
  • Steering transformational national thought-leadership and engineering biology community building through five consecutive years of ;
  • Championing three insightful publications in the areas of engineering biology, cellular agriculture and clean DNA, evolving Ontario Genomics’ scope into market-relevant and ground-breaking spaces.

Most importantly, we commend Bettina’s transformative strategic vision to advance Ontario Genomics’ commitment to realizing homegrown, bio-based solutions to humanity’s greatest challenges: climate change, food insecurity and acute and chronic disease. With Bettina’s commitment to collaboration and entrepreneurial culture, the Ontario Genomics team is set up for success and ready to support Ontario’s thriving genomics community.

Please join us in wishing Bettina all the very best in her new role and stay tuned for more information on Ontario Genomics’ interim leadership plan.

Ontario Genomics-CANSSI Ontario announce 2024 recipient of Postdoctoral Fellowship in Genome Data Science

CANSSI Ontario and Ontario Genomics have awarded a fellowship to support the work of an early-career investigator pursuing research in the areas of genomics and data science with an emphasis on genomic medicine, including, but not limited to, methodology, application, and translation of genomic prediction tools such as polygenic risk scores; human-computer interactions; or novel genomic computational approaches to therapeutic identification.

We are delighted to congratulate the recipient of this Fellowship:

Dustin Sokolowski, Department of Molecular Genetics, University Toronto
Supervisors: Drs. Jared Simpson (University of Toronto and Ontario Institute of Cancer Research) and Melissa Holmes (University of Toronto)
Project: Genome assembly and analysis of the African Mole-Rat family reveals the underpinnings of extreme adaptations related to aging, cancer resistance, and hypoxia tolerance.

Ontario Genomics-CANSSI Ontario Postdoctoral Fellowship in Genome Data Science – Award Recipient: Dustin Jonathan Sokolowski

Dustin Sokolowski is profiled, along with information about his background, research, and proposed research projects here: Dustin Sokolowski

Ontario Genomics is proud to be a partner with CANSSI Ontario to help build research capacity in data science and genomics in Ontario.

About

The Ontario Genomics-CANSSI Ontario Postdoctoral Fellowship in Genome Data Science was created to support research projects and attract, retain, and nurture Highly Qualified Personnel (HQP) combining genomics and data science within Ontario. These HQPs possess a diverse skill set spanning statistics, computational biology, bioinformatics, computer science, epidemiology, engineering, genetics, or mathematics – all indispensable in tackling the complex challenges of our times.

Established in 2000, Ontario Genomics is a not-for-profit organization leading the application of genomics-based solutions to drive economic growth, improved quality of life, and global leadership for Ontario. As part of its strategic vision, Ontario Genomics is dedicated to supporting the development of educational resources that demonstrate how genomics plays a vital role to address key challenges in our society. Ontario Genomics also plays a role in advancing genomics projects and programs across the province by supporting the development of proposals, helping researchers access diverse funding sources, and finding the right industry partners to take this research out of the lab to apply it to the world’s most pressing challenges. Since its inception, Ontario Genomics has raised more than $1.4 billion for genomics applied research in Ontario and directly supported more than 11,00 trainees and jobs.

CANSSI Ontario is the Ontario Regional Centre of the Canadian Statistical Sciences Institute (CANSSI). Its goal is to strengthen and enhance research and training in data science by developing programs that promote interdisciplinary research and enable multidisciplinary collaboration.

CHEO and SickKids join forces to lead the way in data sharing

The All for One Precision Health Partnership is creating a national database for rare diseases

Imagine being very sick, with daily impacts on your wellbeing, family, education and community, but not knowing the cause. This is the experience of many Canadians with a rare genetic disease. Rare genetic diseases affect nearly one million Canadians, and despite extensive clinical testing and investigation, over half of them don’t have a diagnosis.

Over the past four years, clinicians, scientists and researchers in six provinces (British Columbia, Alberta, Manitoba, Ontario, Quebec and Nova Scotia) have been working to evaluate and implement an important clinical genetic test, called genome-wide sequencing (GWS), to help with timely diagnoses for families with rare genetic diseases. The program, called the All for One Precision Health Partnership, began in 2019 and was launched in 2022 with the support of Genome Canada, six regional Genome Centres, and in partnership with provincial governments and end users. Preliminary outcomes show the successful integration of genome-wide sequencing into clinical care can provide a diagnosis for up to 30 per cent of tested families.

The leaders of the six provincial projects are working to the premise that the number of diagnoses, time to diagnosis and equity of access will be improved if diagnostic laboratories providing genome-wide sequencing work together and share data. As part of All for One, a first-of-its-kind national program is being developed to enable secure data sharing between Canadian diagnostic laboratories. This All for One ‘Clinical Genomics Network’ will mean that when a rare disease family receives genome-wide sequencing in one province, their test information may very well help to diagnose a family in another.

The diagnostic laboratories at CHEO and the Hospital for Sick Children (SickKids) are pioneering the sharing of genome-wide sequencing data via the Clinical Genomics Network, contributing data from over 4,000 rare disease patients and family members. This secure data sharing will increase health care providers’ ability to provide answers to families and may decrease their anxious wait for a diagnosis. As more individuals are sequenced and more diagnostic laboratories join the Clinical Genomics Network in the coming months and years, the impact of this network will be amplified across Canada.

“Individually, no single institution or health region can sequence enough people’s DNA to build a comprehensive database to support high-quality interpretation of clinical genome-wide sequencing. This is particularly true for equity-deserving populations who are also underrepresented in current genomic reference datasets. The All for One Precision Health Partnership is changing that and providing a blueprint for other countries around the world.”Dr. Kym Boycott, All for One data sharing lead and Clinical Geneticist at CHEO, and Senior Scientist at the CHEO Research Institute.

“All For One is a ground-breaking portfolio of projects focused on improving health systems locally and regionally, but also contributing to national data sets to accelerate the quality of care for all Canadians. Coordinating and combining our efforts across hospitals, regions and provinces will ensure all patients across Canada are able to receive world-class, cost-effective care.”Dr. Rob Annan, President and CEO of Genome Canada.

For more information on the All for One Precision Health Partnership, go to: GenomeCanada.ca/all-for-one.

All for One - Canada's precision health partnership