Advancing Big Data Science in Genomics Research

In 2013, the Natural Sciences and Engineering Research Council of Canada (NSERC), Genome Canada, the Canadian Institutes of Health Research (CIHR) and the Canada Foundation for Innovation (CFI) partnered on a 2013 Discovery Frontiers call for proposals, focused on advancing big data science in genomics research. This initiative was designed to support the development of tools and methodologies to integrate currently available complex data sets in the fields of ‘omics sciences with each other, as well as with phenotypic data and data from other related fields of biological sciences. It was aimed at building on past and ongoing investments in this area, the most recent being the Bioinformatics and Computational Biology Request for Applications launched in June 2012 by Genome Canada and CIHR.

The result of the Competition was announced April 30, 2014. Federal funding totaling $5.6 million was awarded to the Ontario-led project to support an unprecedented collaboration – both in Canada and internationally – to develop tools that can effectively manipulate vast amounts of data to help find cures for cancer.

Competition for Science and Technology Innovation Centre Operations Support

As part of its commitment to leading-edge research, Genome Canada supported a number of Science and Technology Innovation Centres across Canada. (As of fiscal year 2014-2015 the Science and Technology Innovation Centre model was replaced with the Genomics Innovation Network.). These Centres provided researchers with access to cutting-edge technologies such as DNA sequencing, RNA expression analysis, protein identification, metabolite analysis, bioinformatics and large-scale data analysis, as well as access to new methods and protocols.

Genome Canada provided approximately $24 million in funding to the Science and Technology Innovation Centres from 2010 to 2011, and another $28.6 million in renewed funding for five Centres from 2013 to 2014.

GE³LS Research in Ontario

GE³LS research funded through Ontario Genomics takes two major forms:

Large-scale, stand-alone GE³LS research

Large-scale projects which allow researchers to delve deeply into critical genomics-related economic, environmental, ethical, legal, and social issues, such as the Program on Ethics and Commercialization (formerly the Canadian Program on Genomics and Global Health).

Integrated GE³LS research

Smaller-scale GE³LS research initiatives forming part of large-scale genomics-based research programs. All Large Scale Applied Research Projects (LSARP) funded through Genome Canada must include GE³LS research, in which social scientists and humanists (such as economists, ethicists, and lawyers) work with the scientists to address relevant GE³LS issues. Integrated GE³LS research for previously-funded LSARP projects include the following: