Upcycling Plastics with Genomics for a Zero-Waste Future

Over 29,000 tons of plastic leak into the Canadian environment and oceans annually, creating severe environmental problems, including killing 100,000 marine mammals annually. Another 2.8 million tons of plastic are sent to Canadian landfills, which creates a latent problem for future generations, with only 9% of plastic being recycled.

With growing awareness of the detrimental impacts of plastic, governments and manufacturers are working towards a zero-plastic waste future. Under this paradigm, plastics will be made with recycled or biodegradable components. In this project, a Canadian-led team consisting of multiple universities, governments, and industries will drive a shift to a zero-plastic waste future by harnessing genomics technologies to create a circular economy for plastics.

This team will identify and engineer bacteria and enzymes that can break down plastics into recyclable components or valuable fine chemicals more effectively than chemical conversion-based technologies. Additionally, they will conduct a holistic investigation into the impact of these new plastic biotechnologies on society, the economy, and the environment.

Preliminary estimates indicate recycling could save Canada $500 million annually in costs and create 42,000 jobs in new industries. The market for recovered waste plastic in the textiles sector alone is over $600 million per year. We could also save 1.8 million tons of CO2 equivalents per year in greenhouse gas emissions, ensuring that plastics continue to contribute to the economy without adversely impacting the environment.

“To reach zero plastic waste in Canada by 2030, the Open Plastic consortium will develop novel microbiological technology to support the breakdown of plastic waste into marketable recycled products. Our open science framework will empower trainees of the program and existing companies to build ventures for Canada and export.”

– Dr. Laurence Yang, Assistant Professor, Queen’s National Scholar in Systems Biology, Queen’s University.


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Stopping Foodborne Outbreaks Early

In Canada, consumption of contaminated food causes 4 million illnesses, over 14,000 hospitalizations, and more than 300 deaths each year, with an estimated annual economic burden of approximately $4 billion.

A major impediment to identifying contaminated food is that current surveillance methods rely on sick people to seek medical help instead of public health mechanisms detecting foodborne outbreaks.

The Public Health Agency of Canada (PHAC), the University of Guelph, and Université Laval, are developing a novel, integrated approach to improved foodborne outbreak detection, beginning with genomic detection of foodborne pathogens in raw sewage and monitoring of social media for keywords associated with enteric illness.

The tools, methods, and datasets generated through this project will be translated for downstream operational use into the network of Canadian foodborne surveillance programs through collaborations between PHAC and its federal, provincial, and territorial partners.

Implementation will reduce the number of illnesses and hospitalizations and increase economic savings due to decreased food recalls through faster detection of outbreaks. Another advantage is that this project can be scaled-up for rapid detection of other pathogens and is currently being utilized to monitor levels of SARS-CoV-2, the virus that causes COVID-19, in wastewater, as an early indicator of changing case numbers before clinical presentation.

“As the COVID-19 pandemic continues, we are seeing increasing emergence of variants of concern (VOCs) and variants of interest (VOIs) which threaten the health and wellbeing of Canadians. The funding provided by Ontario Genomics and Genome Canada is helping my team to develop a genomics-based surveillance platform based on analysis of wastewater, providing a customizable tool for use in controlling the spread of infectious diseases, whether they be food or waterborne, or respiratory borne like COVID-19.”

– Dr. Lawrence Goodridge, Director at Canadian Research Institute for Food Safety, University of Guelph.


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Precision Medicine in Early Breast Cancer

Breast cancer accounts for approximately 25% of new cancer cases each year and 13% of all cancer deaths in Canadian women. Breast cancer, which was once considered a homogenous tissue disease, is now known to be a complex, heterogeneous disease. Breast cancer in patients is individual and has different molecular make-ups; therefore, precision oncology promises to significantly improve treatment options.

To better comprehend the individual nature of breast cancer in patients, the implementation of integrated ‘omics solutions is needed to understand the combined effects of genomic and epigenomic changes in driving cancer progression and deliver on the promise of precision medicine.

Emerging research in breast cancer implicates epigenomics in the regulation of multiple cancer processes, including treatment response. Additionally, epigenomics data across cancer driver genes from different ethnic groups shows that molecular processes are influenced by differences in ethnicity. This highlights the diagnostic importance of epigenomic features for equitable delivery of healthcare to patients.

Ontario Institute for Cancer Research (OICR) and Thermo Fisher Scientific have collaborated to develop and validate novel panel-based targeted approaches for the evaluation of epigenetic alterations in breast cancer to address two major needs: improved predictive and prognostic assays for all breast cancer patients and a focused study comparing methylation profiles between cancers in ethnic minority groups.

“We’re investigating the impact of ethnicity in the biology of breast cancer. We are developing new tools to improve the diagnosis of breast cancer patients and accelerate personalized treatment based on the biology of their disease.”

– Dr. Melanie Spears, Principal Research Scientist, Ontario Institute for Cancer Research.


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