Canada launches the most ambitious genomic health research program in Canada history: The Canadian Precision Health Initiative

The Canadian Precision Health Initiative (CPHI) is a $200M investment from the Government of Canada, through Genome Canada, to help transform Canada’s healthcare approach into a modern, precision health system.

Supported by the regional Genome Centres, including Ontario Genomics, this initiative will build Canada’s largest-ever collection of human genomic data —more than 100,000 genomes. This database will represent Canada’s diverse population to ensure precision health innovations benefit all.

CPHI partners will work together to build a coordinated precision health community that will:

  • Build a Canadian alliance for genomics in health to align efforts across Canada’s complex, federated health and research ecosystems.
  • Mobilize and advance the utility of genomic health data, working with academia and industry to ensure they have the right data assets and AI-powered tools to deliver life-saving solutions.
  • Implement data governance and policies ensuring the ethical and responsible use of genomic data.

Ontario Genomics is the lead for 4 awarded projects and the co-lead for 2 awarded projects. These projects will help generate high-quality genomic data that can be shared and securely used by researchers and clinicians across Canada. Learn more about these projects below:

Expanding the Use of Genomics to Unravel Rare Diseases: Care4Rare EXPAND

Project Leaders: Kym Boycott (University of Ottawa/Children’s Hospital of Eastern Ontario Research Institute), Christian Marshall (University of Toronto/Hospital for Sick Children), Francois Bernier (University of Calgary), Jacques Michaud (Université de Montréal/CHU Ste Justine)

Genome Centres: Ontario Genomics, Genome Alberta, Génome Québec

INFANT: Identifying At-risk Newborns from the Analysis of NGS Testing

Project Leaders: Kristin Kernohan, Neal Sondheimer, Melanie Lacaria, Erika Bariciak, Pranesh Chakraborty, Matthew Henderson (Children’s Hospital of Eastern Ontario Research Institute)

Genome Centre: Ontario Genomics

Precision Child Health – Comprehensive Sequencing for Childhood Life-long Disorders

Project Leaders: Stephen Scherer, Seema Mital, David Malkin, Linda Hiraki, Amanda Ricciuto, Gregory Costain, Yiming Wang, Ronald Cohn (Hospital for Sick Children)

Genome Centre: Ontario Genomics

Precision Health Network for Neurodevelopment, Mental Health and Brain Injury

Project Leaders: Evdokia Anagnostou (Holland Bloorview Research Institute), Jennifer Crosbie, Stephen Scherer, Louise Gallagher (The Hospital for Sick Children), Jacob Vorstman (Hospital for Sick Children), Darcy Fehlings (University of Toronto/Holland Bloorview Research Institute), Roger Zemek (Children’s Hospital of Eastern Ontario Research Institute), Danielle Andrade (University Health Network)

Genome Centre: Ontario Genomics

Genomic Evidence for Precision Medicine for Selected Chronic Diseases among Black Peoples in Canada

Project Leaders: Upton Allen (Hospital for Sick Children), Loydie Jerome-Majewska (McGill University), OmiSoore Dryden (Dalhousie University), Juliet Daniel (McMaster University)

Genome Centres: Genome Atlantic, Génome Québec, Ontario Genomics

Longitudinal, Deep-Phenotyped Pediatric Databank of Medical and Drug Therapy Outcomes

Project Leaders: Bruce Carleton (University of British Columbia), Michael Rieder (University of Western Ontario), Maja Krajinovic (Université de Montréal)

Genome Centres: Genome British Columbia, Genome Alberta, Génome Québec, Ontario Genomics

Breaking the Waste Cycle and Embracing the Circular Bioeconomy

Take. Make. Waste. Much of the prosperity of the Industrial Revolution is attributed to inventions that enhanced the ability to extract natural resources from the environment and turn them into products at the largest possible scale. However, the pursuit of efficiency and profitability instilled a mindset that still dominates our modern society: the use of finite resources to make disposable products to maximize profit. This idea, known as the “linear economy”, was a stark contrast to the slower and laborious way of living back in th day, which repurposed everything from building materials, to textiles, and food, back into the life cycle. We have come to see first-hand the devastation caused by a linear economy. Luckily, we have some good news on this – the new circular bioeconomy!

Surrounded by tonnes and tonnes of waste in landfills, oceans and land, the uncomfortable reality is we cannot go on the same way. The good news is that there are solutions. Instead of considering waste as an inherent byproduct of industrial operations, the circular economy framework treats waste as a design flaw and favours options to make waste more valuable and/or curb its production.

The circular economy is based on three key principles:

  1. eliminate waste and pollution
  2. circulate products and materials (at their highest value)
  3. regenerate nature

By “decoupling economic activity from the consumption of finite resources” (Ellen McArthur Foundation) the circular economy enables waste from one product or process to serve as a feedstock for another. Natural systems, such as the carbon and water cycles, demonstrate the kind circularity achievable in other industries. These processes show that circular economies aren’t just ideal—they’re the rule of nature, with our current linear economy being the unnatural exception.

Biomanufacturing (the topic of our blog post #2) thrives when circular economic principles are applied and then translate into sustainability throughout the entire lifecycle of bioproducts. Circularity encompasses several key principles:

  1. Design for Sustainability: Biomanufacturers should design products with the end in mind. This includes considering the environmental impact of materials, production processes, and disposal methods from the start. Waste streams can serve as raw materials for producing valuable substances.
  2. Resource Efficiency: Optimizing the use of feedstocks, energy, and water throughout production minimizes waste.
  3. Reuse and Recycling: Reusing and recycling bioproducts and their components extends their lifespan and reduces the need for new resources.
  4. Regenerative Practices: Practices like sustainable agriculture and responsible harvesting of biomaterials restore ecosystems.

Applying these principles allows us to restore our environment without sacrificing strong economic growth. By focusing on circular manufacturing processes and eliminating waste, industries can regenerate ecosystems while still thriving. Stay tuned for the next post, where we’ll explore how biomanufacturing embraces these principles and provides real-world solutions.

The upcycling process

Ontario’s Biotech Sector is Booming

With $30 million in follow-on funding so far, more companies are joining the BioCreate accelerator

Eight new start-ups have been welcomed into BioCreate, an $11.6-million business accelerator giving financial and commercial support to Ontario biotech companies that are creating game-changing solutions in the food and agriculture, health, and cleantech sectors.

BioCreate was established by Ontario Genomics through a Government of Canada investment of more than $5.6 million from the Federal Economic Development Agency for Southern Ontario (FedDev Ontario).

Each highly vetted company in the program gets $150,000, 18 months of business mentorship, access to critical infrastructure and the chance to pitch to potential investors. Since the program started in 2023, BioCreate companies have raised $30 million in funding and earned sales and revenue of $8.8 million.

Here are the newest BioCreate start-ups:

  • Ardra Bio is a business-to-business biotech company focused on creating sustainable and ethical ingredients that are used in food and cosmetics products.
  • Epiloid is a biotech company focused on finding effective treatments for neurological conditions through data analysis and personalized medicine.
  • Inteligex is a genomics company hoping to change the way traumatic spinal cord injuries are treated by developing drug and stem cell therapies for patients.
  • Materia Bioworks is revolutionizing the way eco-friendly materials are being made by simplifying the process for companies to produce biomaterials like sustainable plastics and packaging.
  • Material Futures is taking all-natural dyes to a new level by using the power of microbes to engineer colourants for a variety of industries including food, cosmetics and fabrics.
  • Mediphage is a genomics company that has created trademark DNA technology to improve the quality of key ingredients in genetic medicines.
  • Noa Therapeutics is a biotech company working to create better treatments for the millions of people struggling with illnesses like eczema, ulcerative colitis and inflammatory bowel disease.
  • ProteinQure is looking to lead the charge in making Ontario a thriving hub of drug development and research, while focusing on breast cancer therapies fuelled by peptides.

BioCreate’s Program Director, Elizabeth Gray, says, “Getting into BioCreate isn’t easy. Our acceptance rate is only 15% because of a stringent selection process that includes a panel of outside experts to make sure our companies have the greatest potential to succeed and get their technologies scaled up and into market quickly.

Congratulations to the eight companies that have joined the BioCreate program,” says the Honourable Ruby Sahota, Minister of Democratic Institutions and Minister responsible for the Federal Economic Development Agency for Southern Ontario (FedDev Ontario). “They will be working hard to improve the lives of Canadians and it is our government’s priority to support our budding companies so they have access to the tools they need to succeed in important sectors like health, food, agriculture and cleantech.

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About Ontario Genomics
Ontario Genomics is a non-profit organization funded by the Government of Ontario and other partners. Since 2000, we’ve been involved with cutting-edge science to find homegrown solutions to challenges the world faces like climate change, food insecurity and in healthcare. Find out more at OntarioGenomics.ca.

About FedDev Ontario
For 14 years, the Government of Canada, through FedDev Ontario, has worked to advance and diversify the southern Ontario economy through funding opportunities and business services that support innovation, growth and job creation in Canada’s most populous region. The Agency has delivered impressive results, which can be seen in southern Ontario businesses that are creating innovative technologies, improving productivity, growing revenues, creating jobs, and in the economic advancement of communities across the region. Learn more about the impacts the Agency is having in southern Ontario by exploring our pivotal projects, our Southern Ontario Spotlight, and FedDev Ontario’s TwitterFacebookInstagram and LinkedIn.

Media Contacts
Maggie Blood
Innovation Communications and Public Affairs Manager
mblood@ontariogenomics.ca

Pillar 1 of the Canadian Precision Health Initiative – Generating population-level genomic data

Genome Canada has launched a new funding opportunity for generation of population-level genomic data, which will be the first pillar of its soon-to-be announced large-scale precision health initiative. The goal of Genome Canada’s planned investment in the first pillar of the initiative is to sequence the genomes of at least 100,000 Canadians, reflecting Canada’s unique and diverse population. This will provide the rich dataset needed to advance research, drive innovation and improve health-care outcomes for all Canadians.

For more information or to apply, please contact Laura Riley, Director, Sector Innovation & Programs, at lriley@ontariogenomics.ca. Letters of Intent are due to Ontario Genomics by 10:00 AM, October 28, 2024.

Download full funding opportunity guidelines

Engineering Biology: Repurposing life’s vast toolkit for better products

In the pursuit of a greener and more sustainable future, biomanufacturing has emerged as a revolutionary approach with the potential to transform industries while minimizing their environmental impact.

Biomanufacturing, also known as bio-based manufacturing or bio-fabrication, is the process of using living things, mostly in the form of micro-organisms (bacteria, yeasts, algae etc.), cells, or enzymes, to produce a wide range of products, including chemicals, fuels, materials, food and ingredients, and even medicines. The applications of biomanufacturing are vast – it has been estimated that up to 60% of the physical inputs of the world’s economy could be produced by biological means! (Ref 1) Using the power of living organisms, biomanufacturing offers an eco-friendly and sustainable alternative to traditional manufacturing methods that rely heavily on non-renewable resources and produce harmful byproducts.

Up to 60% of the physical inputs of the world's economy could be produced by biological means

Ref 1 – The Bio Revolution: Innovations transforming economies, societies,
and our lives, McKinsey & Company (2020)

So how does this work? The first thing to understand is that most of the materials, medicines, and foods we use every day are made up primarily of carbon, like all living things. Most of the carbon we use for manufacturing comes from either naturally occurring sugars or petroleum/oil. Living things have evolved to use carbon in almost infinite ways, giving us an equally vast ability to produce carbon-based products using natural means. So, most of the things we already make can be made by living things!
Many of the products we use every day are made up of carbon, which we extract from naturally occurring sugars or petroleum/oil

But what if we can’t find an organism that naturally creates the product we’re looking for? What if we find one, but it doesn’t produce enough of our molecule of interest to make economic sense? Here is where synthetic biology (synbio, or engineering biology) comes in. Synbio is a multidisciplinary field that brings together biology, chemistry, engineering, and computer science to turn micro-organisms into tiny factories that churn out products better than their natural counterparts. Synbio enables scientists to engineer micro-organisms and other biological systems to perform specific tasks with remarkable precision.

Canada is rich in natural resources, which has led to the development of numerous industries. However, the outcome is that waste produced is often disposed of in less-than-ideal ways. Fortunately, MetaCycler BioInnovations, is looking to change this narrative. The company, which is a spin-off from wasteCANcreate project member Dr. Trevor Charles’ lab at the University of Waterloo, is looking to divert food waste from landfills and produce valuable bio-plastic polymers that are being developed to have the same favourable characteristics as traditional oil-based plastics without creating harmful byproducts along the way. Similarly, YZymes Inc., a start-up company from Dr. Emma Master’s lab (also a wasteCANcreate project member) at the University of Toronto, produces chemical precursors for the production of bio-nylon and various commercially important resins, coatings, and adhesives, from tree biomass and leftover distillers’ grains, which are byproducts of the forestry and corn-based ethanol industries.

Key Advantages to Synbio in Biomanufacturing
  1. Customization: Synbio allows researchers to tailor micro-organisms to produce desired compounds efficiently. This level of customization means that biomanufacturing can be adapted to a wide array of applications, from sustainable materials to biofuels, catering to the needs of a wide variety of industries. It will even allow us to create materials that don’t currently exist.
  2. Resource Efficiency: Biomanufacturing relies on renewable resources, such as plant biomass or waste streams, as feedstock for micro-organisms. This approach reduces dependence on fossil fuels and minimizes greenhouse gas emissions which is less harmful to the environment.
  3. Waste Reduction: Traditional manufacturing often generates significant waste and harmful byproducts. But biomanufacturing has the potential to create products and processes with minimal waste, making it more sustainable and efficient.
  4. Low Carbon Footprint: As biomanufacturing largely relies on biological processes, it results in a smaller carbon footprint compared to conventional manufacturing methods.  
Advantages of synbio in biomanufacturing

Biomanufacturing holds the promise of revolutionizing the way we produce goods and achieve sustainability goals. With synbio platforms as its backbone, this emerging field presents a viable pathway to address the severe climate challenges our planet faces today. By embracing biomanufacturing technologies, we can move closer to a more sustainable world, where economic prosperity goes hand in hand with environmental responsibility. However, there are still challenges that need to be overcome before biomanufacturing can truly revolutionize our world – we’ll talk about that another time on the blog!

In case you missed it, we discussed Turning Waste into Value: A Pathway to Upcycling in our last post – check it out!

Ontario Genomics Welcomes New Board Member

Ontario Genomics Welcomes New Board Member

We’re delighted to introduce you to Lyndal Walker, the newest member of Ontario Genomics’ Board of Directors. Lyndal will enhance the board with a wealth of insight, experience, and expertise in the health and therapeutics space, all of which will help us achieve our strategic vision.

Lyndal Walker

Lyndal Walker is currently the General Manager of Sun Pharma Canada’s Branded Business.

As General Manager, Walker oversees the company’s increasing market investment and expansion of its wide range of medicines, particularly in dermatology, ophthalmology and oncology. Walker is focused on optimizing the power of Sun Pharma’s people, innovative products, global network, and localized research, to accelerate Sun Pharma’s growth in Canada. With over 25 years of experience in global healthcare and the pharmaceutical industry, she continues to unlock value for Canadians and address the unmet needs and gaps in the healthcare system. Read more about Lyndal Walker

Ontario Genomics is also thankful to our retiring board members for their years of deep commitment to our board.

  • Deb (Deborah) Stark served on our board for seven years and played an invaluable role as Chair of the board for five years. Deb brought a wealth of government and agriculture sector experience, while supporting vibrant board development and governance. We are especially grateful to Deb for her steady leadership throughout the challenges of the COVID-19 pandemic.
  • Mark Lundie served on our board for six years and brought fantastic expertise in rare disease and a global pharmaceutical sector perspective. Mark greatly supported our private sector and commercialization programs.
  • Jehoshua Sharma advanced our board with insights into the student perspective while supporting our training initiatives over the past four years. Thank you to our past board members for your contributions to OG!

To learn more about the new member and additional changes to our Board please see our governance page.

Showing Businesses How to Use Science to Their Advantage

A new online course teaches companies to partner with colleges to test their technologies

Micro-Credential Program_Fundamentals of Applied Research copy

It’s a nagging problem countless companies have faced: they have a great idea to improve their products or processes but don’t know how to make it a reality. That’s where Ontario Genomics and Loyalist College come in with a four-course Fundamentals of Applied Research micro-credential program that can get businesses from the idea stage to the testing phase.

The first course is now available and the best part is, it’s online and open to companies across the province. This 10-week, 25-hour, go-at-your-own-pace course walks through the process of how businesses can connect with local college researchers, design, fund and deliver a project that tests the new product or technology they want to incorporate into their operations.

Whether it’s creating a natural food product or ingredient, figuring out more sustainable packaging or improving crop production, applied research projects are a win-win for the community since it’s a lower-risk option that allows local businesses to produce homegrown innovations more efficiently, while also giving college researchers projects to work on.

Fundamentals of Applied Research micro-credential program

Ontario Genomics Strategic Partnerships Manager Michael Dorrington, says, “Most companies don’t realize local colleges offer this kind of access to lab space and expertise to test their ideas. This micro-credential goes through all the steps businesses need to take advantage of this invaluable support available to them.

Amy Harder, Loyalist College Senior Director of Business Development, says, “We’re proud to support businesses and entrepreneurs by offering targeted corporate training programs like this course. It’s through these initiatives that Loyalist strengthens the regional economy and fosters local growth.

Ontario Genomics is a non-profit organization funded by the Government of Ontario and other partners. Since 2000, we’ve been involved with cutting-edge science to find homegrown solutions to challenges the world faces like climate change, food insecurity and in healthcare. Find out more at OntarioGenomics.ca

Blog: When life sciences meet innovation, the world can heal itself

SiREM’s groundbreaking work in Ontario for the world

The marvels of biotechnology are what drive the ground-breaking bioremediation work being done at Guelph-based company SiREM.

You’re probably familiar with bacterial cultures in dairy products like yogurt that give them their trademark taste, smell and texture. SiREM, and their partners at the University of Toronto and the Federated Co-operatives Limited (FCL), have been developing and scaling up bacterial cultures of their own to help various industries clean up chemicals left over from their operations in a safer way that is better for the planet.

SiREM: When life sciences meet innovation, the world can heal itself

The idea is to do away with the destructive “dig-and-dump” method of dealing with contaminated soil and use SiREM’s bioaugmented bacterial cultures instead. Injecting their sustainably produced microbes into groundwater to quickly and naturally break down toxic substances is a far more environmentally friendly and efficient way to clean-up common contaminants in the oil and gas sectors.

Ontario Genomics started supporting this exciting work back in 2016 with a $1 million in funding through the Genomic Applications Partnership Program (GAPP), which according to SiREM’s principal scientist, Sandra Dworatzek, has boosted their success.

Sandra Dworatzek, Senior Scientist at SiREM

Their bioaugmentation cultures have received approval for use by Environment Canada and Health Canada and are currently being used at 15 sites across North America on a wide range of chemicals including chlorinated solvents, benzene, toluene, ethylbenzene, and xylenes.

Getting organized, the genomics way!

Two new hubs will make research easier to manage and access for scientists and industry

Groundbreaking research has the power to move humanity forward in many ways, but it doesn’t do much good if it’s not organized and easy to access. A new $15.8 million program creating two supporting hubs will do away with that problem by getting researchers and industry partners on the same page to turn solid research into real-life use that we can all enjoy.

As part of the Climate-Smart Agriculture and Food Systems (CSAFS) program, nine Interdisciplinary Challenge Teams (ICTs) across Canada are doing critical work to find solutions to climate change and its ravaging impact on our food supply. Ontario Genomics is among a group of investors in these two new organizational hubs that help scientists compile their cutting-edge genomics research in the most efficient way possible.

Climate-Smart Data Collaboration Centre
Climate-Smart Data Collaboration Centre

This $11.1 million data hub will give the ICTs a common framework for data handling and management, so it’s easier to access and share, while also keeping track of their progress.

Researchers: Dr. William Hsiao at Simon Fraser University; Dr. Michelle Edwards at University of Guelph; Dr. Claude Robert at Université Laval

Partners: Ontario Genomics, Genome British Columbia and Génome Québec

Agricultural Genomics Action Centre
Agricultural Genomics Action Centre

This $4.6 million knowledge mobilization and implementation hub will take research from the ICTs and showcase and disseminate the information so that it’s accessible and usable in the real world by partners in the farming, food and beverage and agriculture sectors, as well as policymakers and government.

Researchers: Elizabeth Shantz and Jessica Bowes at University of Guelph; Dr. Nancy Tout at the Global Institute for Food Security, University of Saskatchewan; Dr. Lupin Battersby at Simon Fraser University

Partners: Ontario Genomics, Genome Prairie and Genome British Columbia

Ontario Genomics is a non-profit organization funded by the Government of Ontario and other partners. Since 2000, we’ve been involved with cutting-edge science to find homegrown solutions to challenges the world faces like climate change, food insecurity and in healthcare. Find out more at OntarioGenomics.ca

Unlocking the future of food: The FAO and Ontario Genomics uncover the challenges and opportunities

SynBio2024: Bonus - New Food Innovation Opportunity on Oct 10

The Food and Agriculture Organization (FAO) of the United Nations, alongside Ontario Genomics, is giving you a global perspective on the future of innovation in food, cleantech, and health. Join us in Toronto, from October 7-9, for the sixth edition of Canada SynBio 2024 as we explore how to break through barriers and focus on “Unlocking the Future,” so the bioeconomy can thrive, for Canada and the rest of the world.

You’ll want to book an extra night’s stay in Toronto because on October 10, the FAO, in collaboration with the Department of Agriculture and Agri-Food Canada (AAFC), will hold a stakeholder roundtable meeting on cell-based food production and precision fermentation. This is the third meeting in the series that includes developers, producers, and researchers to apply and present their original products. The call for presenters is open until July 1, additional details here.

Join us and be part of the solution as we address challenges and highlight opportunities for Canada to strengthen its leadership in the ecosystem, and how innovations and engineering biology-based technologies can truly revolutionize society on a global scale. We look forward to seeing you there!