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Databases - Ontario Genomics


Autism Chromosome Rearrangement Database
This resource consists of hand-curated breakpoints and other genomic features relating to autism that derive from publicly available literature such as databases and unpublished data. It undergoes continuous updating with data from in-house experiments and published research, and welcomes data and feedback from the research community.

Barcode of Life Data Systems (BOLD)
BOLD is an accessible database that aids in collection, management, analysis, dissemination, and searching of DNA barcodes. It consists of three components: BOLD-MAS (a repository for DNA barcode records and analytical tools), BOLD-IDS (a species-identification tool that determines taxonomic assignment when possible based on submitted DNA sequences), and BOLD-ECS (for web developers and bioinformaticians to build tools and workflows than can become part of the BOLD framework). Created and maintained in Ontario, BOLD is the definitive global DNA barcode database, with researchers from over 25 countries contributing barcode sequences for over 50,000 species.

Chromosome 7 Annotation Project
This resource comprises a collection of sequences, genes, and other annotations from all databases (e.g., Celera published, Ensembl, NCBI, RIKEN, and UCSC) as well as unpublished data.

Cystic Fibrosis Mutation Database
This database is a collection of mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that acts as a resource for CF research everywhere. It currently contains more than 1,500 mutations and provides information about individual CFTR mutations and their related phenotypes. This database is augmented and maintained by Peter Durie and Julian Zielenski’s research team, originally funded through Ontario Genomics by Genome Canada.

Data Repository of Yeast Genetic Interactions (DRYGIN)
DRYGIN is a database of quantitative genetic interactions of S. cerevisiae derived from the SGA double-mutant arrays conducted in at the Donnelly Centre for Cellular and Biochemical Research. The new portal for searching and visualizing SGA genetic interaction data is available at Cellmap.

Database of Genomic Variants (DGV)
DGV provides a comprehensive summary of structural variation resulting from alterations in the human genome. These changes involve segments of DNA larger than 1kb and insertions and deletions in the range 100bp-1kb. The DGV welcomes data on structural variation in the genome from scientific manuscripts.

Interologous Interaction Database (I2D)
I2D (formerly OPHID) is an online resource for exploring known and predicted mammalian and eukaryotic protein–protein interactions. It contains data for more than 430,000 protein interactions in humans and model organisms (fly, mouse, rat, worm, and yeast).

The Lafora Progressive Myoclonus Epilepsy Mutation and Polymorphism Database
A human Lafora Disease mutation database, developed using a biological database cross-referencing platform. The database contains variations in the two (currently) known genes causing Lafora Disease – EPM2A on chromosome 6q24 and NHLRC1 (EPM2B) on chromosome 6p22.3 – including missense, nonsense, frameshift, and deletion mutations.

StemBase is a publicly available database of Affymetrix DNA microarray and serial analysis of gene expression (SAGE) expression data from samples of human and mouse stem cells and their derivatives.

Structural Genomics Consortium (SGC) Materials and Methods
SGC is a not-for-profit organization that analyses the three-dimensional structure of proteins. It deposits structures (on average, 200 per year) in the Protein Data Bank (PDB), which releases them into the public domain, making them freely accessible.