Blog: When life sciences meet innovation, the world can heal itself

SiREM’s groundbreaking work in Ontario for the world

The marvels of biotechnology are what drive the ground-breaking bioremediation work being done at Guelph-based company SiREM.

You’re probably familiar with bacterial cultures in dairy products like yogurt that give them their trademark taste, smell and texture. SiREM, and their partners at the University of Toronto and the Federated Co-operatives Limited (FCL), have been developing and scaling up bacterial cultures of their own to help various industries clean up chemicals left over from their operations in a safer way that is better for the planet.

SiREM: When life sciences meet innovation, the world can heal itself

The idea is to do away with the destructive “dig-and-dump” method of dealing with contaminated soil and use SiREM’s bioaugmented bacterial cultures instead. Injecting their sustainably produced microbes into groundwater to quickly and naturally break down toxic substances is a far more environmentally friendly and efficient way to clean-up common contaminants in the oil and gas sectors.

Ontario Genomics started supporting this exciting work back in 2016 with a $1 million in funding through the Genomic Applications Partnership Program (GAPP), which according to SiREM’s principal scientist, Sandra Dworatzek, has boosted their success.

Sandra Dworatzek, Senior Scientist at SiREM

Their bioaugmentation cultures have received approval for use by Environment Canada and Health Canada and are currently being used at 15 sites across North America on a wide range of chemicals including chlorinated solvents, benzene, toluene, ethylbenzene, and xylenes.

Blog: Look How Far We’ve Come

Happy DNA Day – Look how far we’ve come!

It was 71 years ago when scientists published groundbreaking research on the structure of DNA. That teamwork grew to become the internationally funded Human Genome Project which culminated in the most complete mapping of the human genome in May 2021. Genomics is all about DNA, and it’s DNA that tells us about life in all forms. It’s the basis of biology which is now fuelling biotechnology innovation. These technologies now have the power to move us away from environmentally damaging manufacturing methods.

After all, climate, food and health are all connected. Climate change is disastrous for food production and supply chains, as well as the health and well-being of everyone on this planet. The good news is, incredible solutions and technologies to address all of these very serious problems currently exist, likely in your own backyard!

Ontario Genomics has been leading the charge in the province since 2000 by supporting cutting-edge science to find homegrown solutions to challenges the world faces like climate change, food insecurity and in healthcare. We’ve done this by raising more than $3.7 billion for genomics applied research in the province which has created more than 20,000 jobs. We have over 330 projects and more than 500 partnerships!

Whether you realize it or not, DNA is all around us. What began decades ago as research to better understand what humans are made of, has since bloomed to include new ways of producing food and improving agricultural techniques as well as clean technology which is providing a new path to make and power the things we need.

One example is the wasteCANcreate program, which is bringing together Canadian researchers and industry partners in Aylmer, Burlington, Orillia, Vancouver and Regina spanning the energy, agriculture and food, plastic films and performance textiles sectors to bring real-world solutions to Ontario, Canada, and the rest of the world.

By using precision fermentation, microbes are used to turn food waste like potato peels into usable products like biodegradable plastics and fibres to create yoga pants! This new method of upcycling also reduces greenhouse gas emissions, replaces the need for petroleum-based plastics and is an economic boost to the province through job creation.

According to Ontario Genomics’ 2021 Cellular Agriculture Report, food biomanufacturing alone could explode to become a $7.5 billion industry creating 86,000 jobs by 2030, with greater growth projected in the long term. That’s why we’re involved with several food and agriculture projects and companies around the province, including the biggest Canadian cellular agriculture project ever that is led by McMaster University where researchers are developing efficient and economical ways to produce cultivated meat on a large scale.

While more commonly heard of cellular/cultivated products like red meat, poultry, seafood, foie gras and pet food are being made, dairy, eggs, honey and even chocolate are created through the same process! Food ingredients like these proteins, enzymes, flavour molecules, vitamins, pigments and fats can also be incorporated with existing products to create hybrid foods. This cellular agriculture technology is also creating textiles such as leather, wool, silk and cotton.

Amazing innovations like this may have seemed like a sci-fi fantasy years ago, but DNA is currently inspiring these kinds of creations here in Ontario. Work like this being done in this province can help propel Canada into global powerhouse status in the biotech-based economy. One way we’re helping to make this happen is through our annual SynBio conference that brings together national and international leaders in the field of engineering biology to build inter-sector partnerships.

Ontario Genomics has a very exciting partnership with FedDev Ontario for our BioCreate accelerator program that provides financial support, business and technical guidance to start-ups in southern Ontario to move the province’s biotechnology scene forward and get game-changing solutions scaled up and put into real world use as quickly as possible.

We’re currently supporting 16 companies in the health, cleantech and food and agriculture sectors, with more on the way! There are a lot of very smart and capable people doing amazing things in the province and it’s also incredibly encouraging to see that half of these companies are either run by women CEOs or have women on their leadership team. That stat alone shows science has also evolved greatly over the years, especially when you consider Rosalind Franklin’s discovery of DNA’s structure in 1953 has been greatly overlooked in the history books.

With all this in mind, we wish you a happy DNA Day – it’s incredible how far we’ve come, and you should feel a part of where we’re going!

Blog: Cracking the Rare Disease Code

EpiSign’s groundbreaking work in Ontario for the world

For years, Ontarians have been hearing about our crumbling health care system but there are many silver linings to the cloudy situation our hospitals are dealing with.

One of them is the groundbreaking work Dr. Bekim Sadikovic at Lawson Health Research Institute and London Health Sciences Centre has been doing with biotech company, Illumina. In their quest to better detect rare diseases, Dr. Sadikovic has created the clinically validated EpiSign test, which uses machine-learning algorithms and compiles them into the EpiSign™ Knowledge Database.

EpiSign: Cracking the Rare Disease Code

Thanks to funding from Ontario Genomics, Genome Canada and their Genomic Applications Partnership Program (GAPP), the EpiSign™ project is helping doctors cut down on long and agonizing diagnosis wait times by efficiently bringing answers and treatment options to more of the 1 in 15 Canadian children born with a rare disease.

Not only does this mean peace of mind and quicker access to the right support for those children, it’s critical relief to our health care system by speeding up the diagnosis process and easing the pressure on hospitals since 1 in 4 pediatric hospital beds are occupied by a child with a rare disease.

Dr. Bekim Sadikovic at Lawson Health Research Institute and London Health Sciences Centre

This incredible work has been an evolution. After all, projects like these don’t happen overnight! It takes many years of collaboration and many rounds of funding. When Dr. Sadikovic’s team applied for their first round of GAPP funding in 2019, they were able to detect 19 different disorders across 30 genes. Five years later, the most recent version of EpiSign™ has 116 different indicators covering 126 disorders. This number will only continue to grow in the years to come and while this much needed innovation was created here in Ontario, it’ll be a benefit to the rest of the world.