Dr. Christine Baes of UofG and Ben Wood of Hybrid Turkeys will be collaborating to adapt and apply genomic tools to improve the health, welfare and productivity of Canadian turkeys. Hybrid Turkeys’ parent company, Hendrix Genetics, has already implemented genomic selection in chickens and pigs, and will now adapt and apply the technology to achieve improvements in feed efficiency, bodyweight, yield, egg production and livability in commercial turkeys. This will lead to estimated economic gains of $39 million over the next five years for the Canadian turkey industry, and will result in environmental benefits due to improved feed efficiency as well as reduced manure and greenhouse gas production.
Dr. Peter Pauls, Michael Emes, and Ian Tetlow of the UofG are working with Benson Hill Biosystems and its Canadian subsidiary, CanolaCo to produce more efficient varieties of canola for Canadian producers. Using a portfolio of trait candidates to improve photosynthesis-one of the most complex systems in plants-and developing these in canola, the project will enhance crop productivity by increasing photosynthetic capacity without negatively impacting seed quality. This will enable commercialization of the improved plants, with the enhanced yields of the canola crop enabling the industry to meet its goal of increasing yield by 53 percent in the next 10 years, growing industry revenues by an estimated $3-$4 billion per year.
Dr. Gisele LaPointe of UofG is working with Maria Pepe of Parmalat Canada, the number one producer of premium aged cheddar in Canada, to increase Parmalat’s manufacturing capacity, and thereby gain efficiency and protect market share. To achieve this, the team will validate and implement metagenomic, metaproteomic and metabolomics tools modified to meet the technical requirements of cheese production. By improving manufacturing processes and controls, the project will overcome current bottlenecks and significantly increase the production capacity of high-quality, competitive, aged cheddar cheese –ultimately increasing the demand for and utilization of Canadian milk.
Nicoya Lifesciences, a nanotechnology sensor company that builds novel products for the life sciences industry, is developing a new LSPR sensor chip technology that enables the accurate measurements of samples from crude or complex media such as water, food matrices, human saliva and more. With a granted patent on this technology, and demonstrated experimental proof of concept, Nicoya will utilise Ontario Genomics’ PBDF investment to begin to commercialize this novel sensor technology for the proteomics and genomics industry.
Elizabeth Edwards and Radhakrishnan Mahadevan of the University of Toronto are developing computational models using microbial genomes and metagenomes to uncover metabolic interactions in complex anaerobic microbial communities. They will identify and validate metabolic gaps pointing to metabolites exchanged among an anaerobic subsurface mixed microbial community that contains microbes used for bioremediation of toxic chlorinated solvents. This project aims to boost the efficiency of dechlorination in groundwater remediation, and resolve metabolic gaps in genome-scale models at the microbial community level.
Drs. David Edgell and Gregory Gloor of the University of Western Ontario are working to develop and test a CRISPR/Cas9 conjugative plasmid system to enable precise user-defined manipulation of the composition of microbial communities. This novel microbial control system aims to enable the selective elimination of individual bacteria from a mixed population. If successful, the microbial control system has broad-ranging applications in basic biomedical research, industrial food-related process, and human health, bringing the scientific community one step further in the quest to harness the power of microorganisms to overcome humanity’s challenges.
Michelle Science of SickKids is collaborating with Bryan Coburn of the University Health Network to investigate the impact of antibiotic treatment on the developing microbiome of infants in Neonatal Intensive Care Units. They aim to identify how the microbiome is affected, and establish whether these changes are associated with short-term or long-term consequences. Their findings will guide decision-making and prescribing practices for infants and neonates in health care facilities, with the ultimate goal of improving patient outcomes.
Manish N. Raizada of the University of Guelph is working to discover probiotic microbes inhabiting the hollow channels of Ontario corn silks. This investigation of the pollen tube microbiome aims to lead to the identification of probiotics which can be applied to silks to combat crop diseases afflicting grain. This has the potential to decrease the requirement for and reliance on pesticides, resulting in more sustainable and effective industry practices – with exciting implications for Ontario corn farmers, grain processors, and local consumers.
As pressures on Canada’s freshwater water supplies grow, the Canadian mining sector is seeking to develop the most sustainable approaches to mining. Dr. Lesley A. Warren of the University of Toronto, along with Dr. Jillian Banfield of University of California, Berkeley, is leading a project that will apply genomics, geochemistry and modeling to mining wastewaters to develop tools to better monitor, manage and reduce sulphur compounds in wastewaters. This project will lower management costs, decrease risk of environmental damage, and better safeguard Canada’s freshwater supplies.
Frontier Agri-Science Inc. and Dr. Dario Bonetta of the University of Ontario Institute of Technology are developing a unique model for both prediction of candidate genes and the validation of effectiveness to improve traits in crops such as wheat, corn and rice. This academic-industry partnership is developing and refining Brachypodium as a highly efficient and novel monocot model system for crop development, with the potential to lead to the development of plant traits with herbicidal tolerance in key food crops.