Bacterial Pathogenesis and Large-Scale Protein Science
Toronto General Hospital, Toronto
Supported by the Ontario Genomics Institute (OGI) via its Genomics Capacity Building (GCB) workshop program, the Ontario Centre for Structural and Functional Genomics hosted a one-day meeting dedicated to “Bacterial Pathogenesis and Large-Scale Protein Science”.
The purpose of this meeting was to open a dialogue between large-scale protein research efforts and the bacterial virulence and pathogenesis community. As an outcome of this meeting, the Ontario Centre for Structural and Functional Genomics launched a series of collaborations with world experts in the field of bacterial pathogenesis. The main goal of these collaborations lies in large scale structural and functional characterization of proteins related to bacterial pathogenesis; specifically, proteins secreted by bacteria in order to manipulate the host cell and proteins involved in antibiotic resistance.
The event (see meeting agenda for more details) attracted more than 110 researchers, mostly from the Toronto research community.
External Speakers
- Brett Finlay, University of British Columbia
- Philippe Sansonetti, Institute Pasteur, France
- Olaf Schneewind, University of Chicago
Outcomes
The Ontario Centre for Structural and Functional Genomics has launched a series of collaborations with world experts in the field of bacterial pathogenesis, including researchers from the Institute Pasteur (France), Yale University (Connecticut), University of Toronto, McMaster University (Hamilton), and The Hospital for Sick Children (Toronto). These collaborations focus on the large scale structural and functional characterization of proteins related to bacterial pathogenesis, specifically proteins secreted by bacteria in order to manipulate the host cell and proteins involved in antibiotic resistance and have thus far led to the following publication:
Singer AU, Rohde JR, Lam R, Skarina T, Kagan O, Dileo R, Chirgadze NY, Cuff ME, Joachimiak A, Tyers M, Sansonetti PJ, Parsot C, Savchenko A. 2008. Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases. Nat Struct Mol Biol. 15(12):1293-301.
Several other publications are in preparation and/or are being submitted.
