Janet Rossant of The Hospital for Sick Children and Brenda Andrews, Jack Greenblatt, Andrew Spence of the University of Toronto led the Functional Annotation of the Mouse Genome project, which generated mouse models for human conditions such as kidney disease and osteoporosis, developed new tools to help characterize Canada’s mutant mice, and established new mouse cell lines that are in high demand by academic and industrial investigators worldwide. Their approaches now promise to provide major insights into human pathologies and highlight effective targets for therapeutic development.
While genomics/biotechnology can help address health challenges currently facing both the developed and developing world, there are growing knowledge gaps in the global community. The Canadian Program on Genomics and Global Health (CPGGH) was developed to help close some of those gaps. Peter Singer and Abdallah Daar’s program on genomics and global health has influenced federal and foreign policy decisions, increased the opportunity for Canadian genomics and biotechnology companies to internationalize in emerging and developing markets, and increased public awareness on the uses and misuses of genomics to address global health challenges. The project also published 60 papers, 22 books and monographs, 17 book chapters and contributions to collective work, and 166 invited presentations
Chromosome 7 contains many genes crucial to development, the cystic fibrosis gene, and is often damaged in some types of leukemia and other cancers. This project, led by Steve Scherer of the Hospital for Sick Children completed a gene map and applied it to disease study, and annotated all pertinent biological features contained in the DNA sequence of human chromosome 7. The project published a seminal manuscript in Science in 2003, describing an accurate DNA sequence and annotation of the entire human chromosome 7 – the first such paper of its kind. Products of this project have been distributed to over 350 investigators worldwide, many of which were probes sent for patient studies or diagnosis.