Ontario Genomics Institute /
2012 Annual Report

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Genomics has increased our understanding of the human body and disease, leading to improved diagnoses, treatments and longer, healthier lives.

Previously completed projects

Identification of Genetic Pathways that Regulate the Survival and Development of Cancer and Cancer Stem Cells

→ Cynthia Guidos

Hospital for Sick Children, Toronto
January 2006 – March 2011
$18.7 million

Genome-Environment Interactions in Type I Diabetes

→ Jayne Danska

Hospital for Sick Children, Toronto

→ Andrew Macpherson

McMaster University, Hamilton
January 2006 – March 2011
$15.1 million

Autism Genome Project

→ Stephen Scherer

Hospital for Sick Children, Toronto
January 2006 – March 2011
$15.6 million

Strengthening the Role of Genomics and Global Health

→ Peter Singer, Abdallah Daar

University of Toronto
April 2006 – December 2010
$10.4 million

Quantum Dot Diagnostics: Simultaneous Genomic and Proteomic Profiling of Multiple Pathogens at Point-of-Care

→ Kevin Kain

University Health Network, Toronto

→ Michael Greenberg

Fio Corporation, Toronto
January 2006 – September 2010
$9.9 million

Automated Three-dimensional Phenotyping of Mouse Embryos

→ Mark Henkelman

Hospital for Sick Children, Toronto
April 2008 – September 2010
$1.4 million

The Dynactome: Mapping Spatio-Temporal Dynamic Systems in Humans

→ Anthony Pawson, Jeff Wrana

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto

→ Shawn Li

University of Western Ontario, London
January 2006 – June 2010
$27.6 million

Software Tools to Simplify Gene Function Prediction

→ Gary Bader, Quaid Morris

University of Toronto
April 2008 – June 2010
$1.9 million

Environmental Barcoding through Massively Parallelized Sequencing

→ Paul Hebert

University of Guelph
April 2008 – June 2010
$1.8 million

Multiplexed MicroRNA Detection on an Electronic Chip

→ Shana Kelley, Ted Sargent

University of Toronto
April 2008 – June 2010
$0.9 million

The Contribution of Genetic Modulators of Disease Severity in Cystic Fibrosis to Other Diseases with Similarities of Clinical Phenotype

→ Peter Durie, Julian Zielenski

Hospital for Sick Children, Toronto
April 2006 – June 2010
$7.6 million

Technologies for Methylome Studies

→ Arturas Petronis

Centre for Addiction and Mental Health, Toronto
April 2008 – March 2010
$0.8 million

Proteomic Technologies for the Study of Rare Cells

→ Daniel Figeys

University of Ottawa
April 2008 – March 2010
$1.5 million

Massively Multiparametric Flow Cytometer Analyzer

→ Scott Tanner

University of Toronto
April 2008 – March 2010
$2.8 million

Integrative Biology

→ Brenda Andrews

University of Toronto
January 2006 – December 2009
$26.8 million

International Regulome Consortium (IRC)

→ Michael Rudnicki

Ottawa Health Research Institute
January 2008 – June 2009
$23.0 million

Canadian Barcode of Life Network

→ Paul Hebert

University of Guelph
April 2005 – June 2009
$11.0 million

Mass Spectrometer-based Flow Cytometer, Methods and Applications

→ John Dick

University Health Network, Toronto
January 2005 – March 2008
$7.8 million

Protein Expression Profiling Platform for Heart Disease Biomarker Discovery

→ Peter Liu, Andrew Emili, David MacLennan

University of Toronto
April 2004 – December 2007
$6.0 million

Assessing Risk for Colorectal Tumours in Canada (ARCTIC)

→ Brent Zanke

Cancer Care Ontario, Toronto

→ Tom Hudson

McGill University and Génome Québec Innovation Centre, Montreal
October 2004 – December 2007
$9.6 million

Segmental Duplications in Neurodevelopmental, Neurological and Behavioural Disorders

→ Stephen Scherer

Hospital for Sick Children, Toronto

→ Xavier Estivill

Centro de Regulació Genòmica, Barcelona
April 2004 – September 2007
$5.2 million

Structural Genomics Consortium (SGC) – Phase I

→ Aled Edwards

University of Toronto
University of Oxford (UK)
Karolinska Institute, Stockholm (Sweden)
July 2003 – June 2007
$105.0 million

Genetic Determinants of Human Health and Disease

→ Katherine Siminovitch

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto
January 2003 – June 2006
$11.0 million

Genomic Analysis of Soil Microorganisms

→ Turlough Finan, Brian Golding

McMaster University, Hamilton
January 2003 – March 2006
$5.9 million

Genomics of the Spruce Budworm and its Viral Pathogens

→ Arthur Retnakaran, Basil Arif

Great Lakes Forestry Centre – NRC, Sault Ste. Marie
January 2003 – March 2006
$4.6 million

Bridging the Emerging Genomics Divide

→ Peter Singer, Abdallah Daar

University of Toronto
January 2003 – March 2006
$2.8 million

Mapping and Isolation of Genes Influencing Severity of Disease in Cystic Fibrosis

→ Peter Durie, Lap-Chee Tsui

Hospital for Sick Children, Toronto
October 2002 – March 2006
$6.4 million

Functional Genomics of Type 1 Diabetes

→ Jayne Danska

Hospital for Sick Children, Toronto
January 2003 – March 2006
$8.5 million

The Stem Cell Genomics Project

→ Michael Rudnicki

Ottawa Health Research Institute
July 2002 – March 2006
$11.1 million

Proteomics and Functional Genomics – An Integrated Approach

→ Brenda Andrews, Cheryl Arrowsmith

University of Toronto
July 2002 – March 2006
$15.0 million

Functional Genomics and Proteomics of Model Organisms

→ Jack Greenblatt, Andrew Spence, Brenda Andrews

University of Toronto
October 2001 – March 2006
$26.5 million

Development and Applications of Functional Genomics Technologies

→ James Woodgett

University Health Network, Toronto
October 2002 – December 2005
$8.8 million

The Biomolecular Interaction Network Database (BIND)

→ Christopher Hogue

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto
April 2002 – December 2005
$23.1 million

Genomic Resource Core Facility

→ Stephen Scherer, Lap-Chee Tsui

Hospital for Sick Children, Toronto
October 2001 – December 2005
$18.0 million

Proteomics Technology Core Facility (PTCF)

→ Jack Greenblatt

University of Toronto

→ Gilles Lajoie

University of Western Ontario, London
October 2001 – December 2005
$8.6 million

Genetic Determinants of Human Health and Disease – Annotation of Chromosome 7

→ Stephen Scherer

Hospital for Sick Children, Toronto
October 2001 – September 2005
$1.8 million

Canadian Program on Genomics and Global Health

→ Peter Singer, Abdallah Daar

University of Toronto
October 2001 – September 2005
$6.2 million

Functional Genomics and Proteomics of Model Organisms

→ Janet Rossant, Anthony Pawson

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto
October 2001 – September 2005

Functional Genomics of Arabidopsis

→ John Coleman

University of Toronto
July 2002 – September 2005
$1.8 million

Fiber Optic Nucleic Acid (FONA) Biosensor-based Gene Profiling: Proof of Principle by Screening for Drug Leads for Orphan Neurodegenerative Disorders and SNP Analysis

→ Alex MacKenzie

Children’s Hospital of Eastern Ontario, Ottawa

→ Paul Piunno, Ulrich Krull

University of Toronto at Mississauga
July 2002 – June 2005
$2.8 million

Viral Proteomics

→ Lori Frappier, Christian Burks

Affinium Pharmaceuticals, Toronto
July 2002 – December 2004
$6.3 million

Dollar amounts are total approved project costs as of March 31, 2012